General Information

  • ID:  hor004836
  • Uniprot ID:  B3EWM7
  • Protein name:  Adipokinetic hormone
  • Gene name:  N/A
  • Organism:  Delia radicum (Cabbage root fly) (Anthomyia brassicae)
  • Family:  AKH/HRTH/RPCH family
  • Source:  animal
  • Expression:  Detected in larvae and adults. |In larvae, expressed in the ring gland but not in midgut, CNS, thoracic perisympathetic organs (tPSO) and abdominal perisympathetic organs (aPSO) (at protein level). In adults, expressed in corpora cardiaca and corpora alla
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Delia (genus), Anthomyiinae (subfamily), Anthomyiidae (family), Muscoidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QLTFSPDW
  • Length:  8
  • Propeptide:  QLTFSPDW
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T8 Tryptophan amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Probably causes a marked increase in hemolymph carbohydrate.
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004836_AF2.pdbhor004836_ESM.pdb

Physical Information

Mass: 111812 Formula: C47H64N10O14
Absent amino acids: ACEGHIKMNRVY Common amino acids: DFLPQSTW
pI: 3.75 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 3
Hydrophobicity: -55 Boman Index: -1000
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 48.75
Instability Index: 6967.5 Extinction Coefficient cystines: 5500
Absorbance 280nm: 785.71

Literature

  • PubMed ID:  20869420
  • Title:  Neuropeptides associated with the central nervous system of the cabbage root fly, Delia radicum (L).
  • PubMed ID:  22848525
  • Title:  Peptidomics of the agriculturally damaging larval stage of the cabbage root fly Delia radicum (Diptera: Anthomyiidae).